MedSciNet and Cholestasis Research

Professor Catherine Williamson

MedSciNet has completed development of an on-line database to support Cholestasis research at King’s College London in the Maternal and Fetal Disease group, led by Professor Catherine Williamson.

Cholestasis of pregnancy (known as Obstetric Cholestasis or Intrahepatic Cholestasis of Pregnancy) is the commonest pregnancy-specific liver condition and affects about 1 in 140 pregnancies in the UK every year. Mothers suffer from intense itching (pruritus) and blood tests show raised serum bile acid levels. The heath of the fetus can also be threatened.

Prof Williamson and her team have been researching this condition for a number of years. In addition to a large archive of samples and clinical information, new patients are being continuously recruited prospectively to a range of studies.

MedSciNet programmers have worked in collaboration with members of the team, (scientists, clinicians and midwives) to generate a database capable of supporting all of the research activities of the group.

In addition to collating a huge amount of clinical data from multiple visits from patients, the database can accommodate historical and archive data, multiple cross referencing and indexing of research samples and research results and has been designed to export information in a range of formats to suit the scientists and clinicians needs.