MedSciNet has implemented the online database for the Comparison Of Respiratory Support After Delivery on infants born before 28 weeks gestational age (CORSAD28) study. It is a randomized control trial to test a new medical device designed to reduce the need for intubation and mechanical ventilation in extremely preterm infants.
Extremely preterm infants (<28 weeks gestational age) have immature lungs and often have difficulties transitioning to breathing after birth. There are several respiratory support treatments available to aid in this transition, such as continuous positive airway pressure (CPAP), aiming to establish stable spontaneous breathing. When this is not possible, infants are intubated and mechanically ventilated, which is associated with higher morbidity compared to infants breathing with CPAP support.
In Sweden, 60% of infants born before 28 weeks of gestational age were intubated in 2012-2013 (Swedish Neonatal Quality Register). The additional work that the infant must perform, when breathing through a CPAP support system (imposed work of breathing) may be an important factor for treatment failure and subsequent need for intubation. A new respiratory support device that is more pressure stable and has low imposed work of breathing has been developed in Östersund and at the Karolinska University Hospital. The CORSAD28 trial will compare the new device with a reference T-piece resuscitation system, in respiratory support for the first 10-30 minutes of life. The new device is undergoing CE marking and has been licensed for production and commercialization.